Title
Markers of Inflammation in Children With Severe Malarial Anaemia
Document Type
Article
Publication Date
2000
Abstract
OBJECTIVE. To investigate if severe malarial anaemia is associated with a specific immune response pattern, we determined serum levels of neopterin (a marker of activation of macrophages by interferon-γ) and of the anti- inflammatory cytokines, interleukins 4 and 10. METHODS. Zambian children < 6 years of age presenting to a rural hospital with cerebral malaria were studied. Twenty-one children with admission haemoglobin concentrations ≤ 5 g/dl were classified as having severe anaemia and 40 with haemoglobin concentrations ≥ 7 g/dl served as a control group. RESULTS. Logistic regression modelling indicated that a 10-fold rise in serum neopterin concentrations was associated with a 50-fold increase in the estimated odds of having severe anaemia (P = 0.015), while a 10-fold rise in serum interleukin 4 concentrations was associated with a 10-fold decrease in the estimated odds of having severe anaemia (P = 0.023). Increasing serum interleukin 10 concentrations, measured in less than half of the subjects, were associated with a nonsignificant reduction in the odds of having severe anaemia (P = 0.095). CONCLUSION. Development of severe malarial anaemia may be directly associated with serum neopterin concentrations and inversely correlated with serum interleukin 4 levels.
Recommended Citation
Biemba, G.; Gordeuk, V. R.; Thuma, Philip; and Weiss, G., "Markers of Inflammation in Children With Severe Malarial Anaemia" (2000). Biology Educator Scholarship. 69.
https://mosaic.messiah.edu/bio_ed/69
Comments
Biemba, G., Gordeuk, V. R., Thuma, P., & Weiss, G. (2000). Markers of inflammation in children with severe malarial anaemia. Tropical Medicine and International Health, 5(4), 256–262. https://doi.org/10.1046/j.1365-3156.2000.00545.x