Title

Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation

Authors

Jennifer L. Szczytkowski-Thomson, Messiah UniversityFollow
Donald Lysle

Document Type

Article

Publication Date

9-2010

Abstract

This study investigates the role of basolateral amygdala (BLA) dopamine in heroin-induced conditioned immunomodulation. Animals underwent conditioning in which heroin administration was repeatedly paired with placement into a conditioning chamber. Six days after the final conditioning session animals were returned to the chamber and received intra-BLA microinfusions of dopamine, D₁ or D₂, antagonist. Antagonism of D₁, but not D₂, receptors within the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS, TNF-α and IL-1β. This study is the first to demonstrate that the expression of heroin's conditioned effects on proinflammatory mediators require dopamine D₁ receptors within the BLA.

Comments

Originally published as:

Szczytkowski-Thomson, J. L., & Lysle, D. T. (2010). Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation. Journal of Neuroimmunology, 226(1–2), 38–47. https://doi.org/10.1016/j.jneuroim.2010.05.029

Recommended Citation

Szczytkowski-Thomson, Jennifer L. and Lysle, Donald, "Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation" (2010). Psychology Educator Scholarship. 33.
https://mosaic.messiah.edu/psych_ed/33