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This study investigates the role of basolateral amygdala (BLA) dopamine in heroin-induced conditioned immunomodulation. Animals underwent conditioning in which heroin administration was repeatedly paired with placement into a conditioning chamber. Six days after the final conditioning session animals were returned to the chamber and received intra-BLA microinfusions of dopamine, D1 or D2, antagonist. Antagonism of D1, but not D2, receptors within the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS, TNF-α and IL-1β. This study is the first to demonstrate that the expression of heroin's conditioned effects on proinflammatory mediators require dopamine D1 receptors within the BLA.


Originally published as:

Szczytkowski-Thomson, J. L., & Lysle, D. T. (2010). Dopamine D1 receptors within the basolateral amygdala mediate heroin-induced conditioned immunomodulation. Journal of Neuroimmunology, 226(1–2), 38–47.

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