Date of Award
Spring 2021
Document Type
Open Access Thesis
Department
Chemistry and Biochemistry
First Advisor
Dr. Anne Reeve
Abstract
Type 2 diabetes is a serious metabolic disease with a growing need for improved therapeutics. Traditional antidiabetic drugs can assist with the maintenance of blood glucose levels in diabetics but are not optimal treatments due to side effects. PTP1B is a validated therapeutic target for type 2 diabetes, as it acts as a negative regulator in the insulin signaling pathway. Inhibiting PTP1B may allow for increased insulin sensitivity, leading to glucose homeostasis and improved metabolism. In the past 3 allosteric sites were identified as targets for PTP1B inhibition. This study analyzes the validity of these sites and the possibility of other allosteric sites through computational methods, organic synthesis, and enzymatic assays. A new allosteric site is identified and used to improve a computational method for testing possible inhibitors of PTP1B.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Recommended Citation
Codd, Sarah and Reeve, Anne, "Developing a reliable computational method to determine the allosteric sites to be targeted in finding non-aggregating allosteric inhibitors of PTP1B" (2021). Honors Projects and Presentations: Undergraduate. 416.
https://mosaic.messiah.edu/honors/416
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Chemicals and Drugs Commons, Diseases Commons
