Title

Iron Chelation as a Chemotherapeutic Strategy for Falciparum Malaria

Document Type

Article

Publication Date

1993

Abstract

To examine the effect of iron chelation against human malaria, 37 Zambians with asymptomatic Plasmodium falciparum infections were randomly assigned to 72-hr infusions of desferrioxamine B or placebo. Mean concentrations of ring forms decreased significantly with desferrioxamine B (P < 0.001) but not with a placebo. Over seven days of observation, mean parasite concentrations remained at the initial levels in six individuals originally given placebo, but decreased promptly with administration of desferrioxamine B (P = 0.001). Mean parasitemia was significantly lower for up to four weeks in 16 subjects treated with desferrioxamine B when compared with the eight who had received placebo only (P = 0.027). We conclude that iron chelation has antiplasmodial activity and may offer a new therapeutic strategy for falciparum malaria.

Comments

Gordeuk, V., et al. (1993). Iron chelation as a chemotherapeutic strategy for falciparum malaria. American Journal of Tropical Medicine and Hygiene 48(2) 193-197.

© 1993 American Journal of Tropical Medicine and Hygiene. Original published version available at https://doi.org/10.4269/ajtmh.1993.48.193.

Gordeuk, V. R., Thuma, P. E., Brittenham, G. M., Biemba, G., Zulu, S., Simwanza, G., Kalense, P., M’Hango, A., Poltera, A. A., Aikawa, M., & Parry, D. (1993). Iron chelation as a chemotherapeutic strategy for falciparum malaria. The American Journal of Tropical Medicine and Hygiene, 48(2), 193–197. https://doi.org/10.4269/ajtmh.1993.48.193

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