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The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.


Stresman, G., et al. (2012). Malaria Research Challenges in Low Prevalence Settings. Malaria Journal 11, Article 353.

© 2012 the authors. Published under Creative Commons Attribution License. Original published version available at

Stresman, G., Kobayashi, T., Kamanga, A., Thuma, P. E., Mharakurwa, S., Moss, W. J., & Shiff, C. (2012). Malaria research challenges in low prevalence settings. Malaria Journal, 11(1), 353.

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